Endocrine Abstracts

Background: Growth hormone (GH) deficiency(GHD) in childhood is associated with impairment in linear growth. GH therapy enables the achievement of normal adult height in most cases. The response is variable and factors influencing height outcome are still not clearly defined.Objective: To evaluate near adult height (NAH) in a single center cohort of childhood onset GHD patients treated with GH and investigate main predictors of final height (FH).<p c...

Background: Endothelial dysfunction is considered an early step in the development of atherosclerosis, while an increased intima-media thickness (IMT) represents one of the earliest morphological changes in the arterial wall in the process of atherogenesis. Only a few studies have investigated endothelial dysfunction and IMT in GHD children and results are still inconsistent.Objective: Aim of our study was to evaluate the effects of GHD and GH treatment ...

Background: Primary Adrenal Insufficiency (PAI) is a rare life-threatening disorder. Data on etiology and outcome of PAI in childhood are scanty, with the exception of Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD). The aim of our study is to evaluate etiology, morbidity and long-term outcome of PAI in a large cohort of children and characterize clinical presentation in subjects with PAI not due to 21OHD CAH.Material and me...